This study by the first, was carried out to evaluate and comparing Disposal waste management in Karaj's hospitals in 1387. Interview and observation methods were used to collect data and the study tool was a questionnaire. Data were analyzed by the SPSS, using chi-square and t-test. Regarding the condition of infectious waste generation, 64% of the hospitals had a good grade. Source separation of the waste were equipped in 100% of the units but did not completed and the domestic waste were mixed by the infectious waste at transportation time. But In general that function was in a good condition. the trashcans were in a good condition in 100% of these hospitals and in all of them infectious waste was kept in containers with special waste sacks and the collection of waste in 81/8% of the hospitals was done in special bins and 81/8% of temporary waste storage had enough place for the wastes. In all of hospitals waste wards equipped in three parts in day and thus the frequency of gathering waste was adequate. In all of these hospitals carrying and transportation of waste material equipped with trolleys, thus 100% of these were in a good condition. In 9.1% of these hospitals, infectious wastes was separated and disinfected by autoclaves and 9.1% of these hospitals had incineration facilities and therefore this function was in a poor condition. Unfortunately, the results have shown that the waste management in these hospitals was not on an appropriate level and in general, source separation, collection system from different wards, temporary storage and transportation in these hospitals were adequate, but the final disposal was very poor.